CLINICAL-PATIENT STUDIES Successful treatment of a child with a primary intracranial rhabdomyosarcoma with chemotherapy and radiation therapy
نویسندگان
چکیده
Primary rhabdomyosarcoma of the central nervous system (CNS) is rare in both adults and children (Taratuto et al. (1985) Acta Neuropathol (Berl) 66(2): 98–104). The outcome in the majority of cases is poor, and many cases are associated with early mortality (Celli et al. (1998) J Neurooncol 36(3):259–267). There are very few cases reported in the literature of survival beyond 2 years after diagnosis. We report a case of primary intracranial embryonal rhabdomyosarcoma in a 5-year-old girl who was treated successfully with local radiation therapy (RT) and a combination of two different chemotherapeutic regimens. The patient is clinically well 26 months after diagnosis, with no definitive evidence of residual disease.
منابع مشابه
Dental Complications Following Radiation Therapy in Rhabdomyosarcoma Patient: Report of a rare Case
Rhabdomyosarcoma is a malignant neoplasm and the most common soft tissue sarcoma in children. The current frontline treatment for rhabdomyosarcoma is a multi-modal approach, comprising chemotherapy, surgical resection, and/or radiation therapy. Radiation therapy during odontogenesis can lead to delayed sequel such as hypodontia, microdontia, and dwarfed teeth with underdeveloped roots. This cas...
متن کاملTreatment of a Child with Refractory Acute Myeloid Leukemia with Humanized Anti-CD33 Monoclonal Antibody: A Case Report and Review of Drug Development
Background: The induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. For patients with relapsed or refractory disease, alternative chemotherapy agents are available. Monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozog...
متن کاملI-6: Fertility Preservation in Male Patient with Cancer
Studies suggest that the ability to have biological children is of great importance to many people. The cancer and its treatment often pose a threat to fertility. Rates of permanent infertility and compromised fertility after cancer treatment vary and depend on many factors. Male infertility can result from the disease itself (best documented in patients with testicular cancer and Hodgkin’s lym...
متن کاملRhabdomyosarcoma: Nose Presenting As Second Primary with Carcinoma Tongue
Introduction Presence of two primary malignancies is rare and occurs in 3-5% of the cancer patients. As per our extensive internet research, this is the only reported case of a synchronous sino-nasal embryonal rhabdomyosarcoma with squamous cell carcinoma-tongue. The case report is important because of the rare diagnosis and the challenge we faced in the diagnosis and treatment of the pat...
متن کاملSystemic Targeted Alpha Radiotherapy for Cancer
Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...
متن کامل